Tamir Gonen

Assistant Professor of Biochemistry

        1995 -   BS - Inorganic Chemistry and Biochemistry, University of Auckland, NZ
        1998 -   First Class Honors - Membrane Proteomics, University of Auckland, NZ
    1999 -   PhD - X-ray Crystallography and Membrane Biochemistry, University of Auckland, NZ
        2002 -   Postdoctoral Fellow - CryoElectron Microscopy, Harvard Medical School, USA
    2005 -   Assistant Professor of Biochemistry, University of Washington, USA

    206 616 7565 (office)
        206 616 8529 (lab and computation suite)
        206 543 7258 (cryo EM facility)
        206 685 1792 (fax)
        tgonen@u.washington.edu

Other links: Department of Biochemistry - Gonen Website
MCB - Gonen Website

BMSD - Gonen Website

Positions and Honors

1996                  Deans list - Organic Chemistry, University of Auckland, New Zealand.
1996                  Deans list - Inorganic Chemistry, University of Auckland, New Zealand.
1997                  Center for Gene Technology Research Scholarship, University of Auckland, New Zealand.
1997                  Deans list - Inorganic Chemistry, University of Auckland, New Zealand.
1998                  Senior Prize in Biological Sciences, University of Auckland, New Zealand.
1998                  First Class Honors in Biological Sciences, University of Auckland, New Zealand.
1999                  University of Auckland Doctoral Scholarship, University of Auckland, New Zealand.
2000                  Contestable Travel Fund Award, University of Auckland, New Zealand.
2001                  Contestable Travel Fund Award, University of Auckland, New Zealand.
2002-2005      Harvard Medical School Postdoctoral Fellow, Boston, MA, USA.
2005-                Assistant Professor of Biochemistry, Department of Biochemistry, University of Washington, Seattle, WA, USA.
2005-              Director, Cryo Electron Microscopy Facility, Department of Biochemistry, University of Washington, WA, USA.
2006                  Plenary Lecture, EABS & BSJ 2006, Okinawa, Japan.
2007                  Organizing Committee and Session Chair, US-Japan Cooperative Cataract Research Group Meeting, Hawaii, USA.

Publications

2008

Zheng H., Olia A.S., Gonen M., Andrews S., Cingolani G. and Gonen T. A conformational switch in bacteriophage P22 portal protein primes genome injection. Molecular Cell 29: 376 - 383 (2008).

Reichow L.S. and Gonen T. Non-canonical binding of calmodulin to aquaporin-0: implications for channel regulation. Structure - In Press (2008).

Andrews, S.A., Reichow, L.S. and Gonen T. Electron crystallography of aquaporins. IUBMB Life 60: 430 - 436 (2008).

Gonen T., Hite R.K., Cheng Y., Petre B.M., Kistler J. and Walz T. Polymorphic assemblies and crystalline arrays of lens tetraspanin MP20. Journal of Molecular Biology 376: 380-392 (2008).

Engel A., Fujiyoshi Y., Gonen T. and Walz T. Junction-forming aquaporins. Current Opinion in Structural Biology 18: 229-235 (2008).

2007

Franck A.D., Powers A.F., Gestaut D.R., Gonen T., Davis T.N. and Asbury C.L. Tension applied through the Dam1 complex promotes microtubule elongation providing a direct mechanism for length control in mitosis. Nature Cell Biology 9(7): 832-837 (2007).

Hite R.K., Gonen T., Harrison S.C. and Walz T. Interactions of lipids with aquaporin-0 and other membrane proteins. Pflugers Archive - European Journal of Physiology 456: 651-661 (2007).

Viadiu H., Gonen T. and Walz T. Projection map of aquaporin-9 at 7 A resolution. Journal of Molecular Biology 367: 80-88 (2007).

2006

Gonen T. and Walz T. The structure of aquaporins. Quarterly Reviews of Biophysics 39, 4: 361-396 (2006).

2005

Gonen T., Cheng Y., Sliz P., Hiroaki Y., Fujiyoshi Y., Harrison SC. and Walz T. Lipid–protein interactions in double layered two dimensional crystals of AQP0. Nature 438: 633-638 (2005).

2004

Gonen T., Sliz P., Cheng Y., Kistler J. and Walz T. Aquaporin-0 membrane junctions reveal the structure of a closed water pore. Nature 429 (6988): 193-7 (2004).

Gonen T., Cheng Y., Kistler J. and Walz T. Aquaporin-0 membrane junctions form upon proteolytic cleavage. Journal of Molecular Biology 342(4): 1337-45 (2004).

2003

Grey AC., Jacobs MD., Gonen T., Kistler J. and Donaldson PJ. Insertion of MP20 into lens fibre cell plasma membranes correlates with the formation of an extracellular diffusion barrier. Experimental Eye Research 77(5): 567-74 (2003).

2001

Gonen T., Grey AC., Jacobs MD., Donaldson PJ. and Kistler J. MP20, the second most abundant lens membrane protein and member of the tetraspanin superfamily, joins the list of ligands of galectin-3. BioMed Central - Cell Biology 2: 17 (2001).

2000

Gonen T., Donaldson PJ. and Kistler J. Galectin-3 – a new adhesion molecule in the lens. Investigative Ophthalmology and Visual Science 41: 199-203 (2000).

1999

Kistler J., Merriman-Smith R., Young M., Gonen T., Cowan D. et al. Molecular solutions to tissue transparency. N.Z. Biosciences August: 35-37 (1999).

Baker EN., Metcalf P., Smith C., Arcus V., Ashton R., Baker H., Banfield M., Cross J., Drew D., Goldstone D., Gonen T., Haebel P. et al. More than a pretty picture. N.Z. Biosciences August: 32-35 (1999).